In Monster Baby Rescue!, players will take care of their sad, lost and ill "Baby monsters" who got lost to us from fantastic world. Every player picks their own "Monstie" — Dragon, Mandrigora, Ork, Basilisk, or Kerberos — and with the help of tiles displayed on the table takes care of it. There are tiles to groom particular parts of bodies, cosy places, tiles with playgrounds, diamonds to play or decorate with, and magicians (vets). These tiles have different "prices" which are paid by different number of steps of your Monstie on the time track. The next player is the one who is the furthest behind (takes the cheapest tiles from the table).

Players will gain points for bonuses on tiles and also for the levels, they groom, improve, and take care of their Monsties.