Doctor Who Fluxx takes the basic gameplay of Fluxx and combines it with multiple regenerations of the Doctor, various companions, Gallifreyan technology, K-9, Cybermen, Daleks, Weeping Angels, and the Master.

Fluxx is a card game where the cards themselves determine the current rules of the game. By playing cards, you change multiple aspects of the game: how to draw cards, how to play cards, and how to win.

At the beginning of the game, each player holds three cards and on a turn a player draws one card, then plays one card. By playing cards, you can insert new rules into play that change many aspects of the game: how many cards to draw or play, how many cards you can hold in hand or keep in front of you, and (most importantly) how to win the game.