Includes eight Disease cards:

• Pox
• Scurvy
• Typhus
• Beriberi
• Fever
• Sailor’s Bane
• Sea-Sickness
• Piratitis!

At the beginning of the game, you put one of them into play and shuffle the rest into the deck. Each disease has a unique ability, and they affect all players. Disease cards don't count as permanents, and whenever you draw one it is played immediately.

As your action in a turn, you can mix all Disease cards from play back into the deck - this is the only way to get rid of them, but it might be worth it...especially if all of them are in play!