Travel back in time to Greece in 370 BCE on the island of Kos. Hippocrates has just passed away and that has led to a lot of doubt regarding the durability of his medical activities. As one of his successors, you lead a team of doctors with the goal of continuing the treatment of patients in the temple of Asclepios, later known as the first hospital in history. Be the right successor of Hippocrates and increase your reputation, so that patients from all across the Mediterranean will come with the hope of receiving the best treatment ever.

The game lasts four rounds, with every round divided into five phases:

1. Kalosorisma — Players welcome up to three patients in their hospital. You will need to select your patients carefully as all patients need urgent help, and some may be easier to treat than others, but make sure to help the most in need or you will lose reputation as a doctor.

2. Pliromi — You will have to remunerate your doctors or risk their departure.

3. Stratologisi — In this phase, players attempt to hire new doctors and purchase medicine kits. If a player gets both, they receive a bonus.

4. Therapeia — This is the time to treat patients. Players will have to carefully puzzle and link the right patients to the right doctors to maximize their assets.

5. Exis — Players count victory and reputation points, and ready the board for the next round.

Hippocrates combines auction bidding, resource management, tile placement and more to create an exciting mix that will challenge each player to best manage their patients and try to become Hippocrates' worthy successor.