In Villainous: Bigger and Badder, players takes control of one of three Disney characters, each one a villain in a different Disney movie, specifically Syndrome (The Incredibles), Lotso (Toy Story 3), and Madam Mim (The Sword in the Stone). Every player has their own villain deck, fate deck, player board, and 3D character.

On a turn, the active player will move their character to a different location on their player board, takes one or more of the actions visible on that space (often by playing cards from their hand), then refills their hand to four cards. Cards are items, allies, effects, and conditions. You need to use your cards to fulfill your unique win condition.

One of the actions lets you pick another player, draw two cards from that player's fate deck, then play one of them on that player's board, covering two of the four action spaces on one of that player's locations. The fate deck contains items, heroes, and effects from that villain's movie, and these cards let other players mess with that particular villain.

In further detail, just like in The Incredibles, Syndrome will face off against Frozone and the Parr family, using his minions and advanced technology to come out ahead. To win as Syndrome, players will need to upgrade the Omnidroid, then defeat it and all heroes in his realm. Lotso aims to control Sunnyside Daycare by reducing four heroes' strength (utilizing a game mechanism new to Disney Villainous) and moving those heroes to the toddlers' Caterpillar Room. Finally, those playing as Madam Mim will have to win a wizard's duel against Merlin, using Mim's Transformations to defeat Merlin's.

Villainous: Bigger and Badder is playable on its own, and its characters may also face off against those in the other Disney Villainous games.